Amy Ibrahim
Research Fellow
Moon Group, LSHTM, London
Research
I work within the Moon Group at LSHTM investigating how the inrtacellular parasite, Plasmodium knowlesi invades human erythrocytes. My research is funded under a Wellcome Trust Discovery Award. I use CRISPR-Cas9 based genome editing to target known and unknown genes associated with erythrocyte invasion and investigate parasite phenotypes.
Previously, I have worked on whole genomoe sequencing for malaria parasites, using both Illumina and Oxford Nanopore systems, and I use the Nanopore MinION frequently to assess the genomics of modified parasite lines.
Associated publications
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Ibrahim, A. et al. Genome sequencing of Plasmodium malariae identifies continental segregation and mutations associated with reduced pyrimethamine susceptibility. Nature communications. 15, 10779 (2024).
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Ibrahim, A. et al. Population genomic study of Plasmodium vivax malaria in seven Brazilian states and across South America. Lancet Reg. Heal. - Am. 18, 100420 (2023).
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Ibrahim, A. et al. Selective whole genome amplification of Plasmodium malariae DNA from clinical samples reveals insights into population structure. Sci Rep. 10, 10832 (2020).
Lab Training
Computational Training
Initial computer set up for coding - mac users
Initial computer set up for coding - windows users
Initial computational set up for coding - Linux servers
Nanopore analysis for custom barcodes
Nanopore analysis for genome assembly
Nanopore analysis for genome mapping and checking specific genes (basic)